A Big Alzheimer's Drug Study Is Proceeding Cautiously Despite The Pandemic

Oct 20, 2020
Originally published on October 20, 2020 3:15 pm

Medical research was an early casualty of the COVID-19 pandemic.

After cases began emerging worldwide, thousands of clinical trials unrelated to COVID-19 were paused or canceled amid fears that participants would be infected. But now some researchers are finding ways to carry on in spite of the coronavirus.

"It's been a struggle of course," says Joshua Grill, who directs the Institute for Memory Impairments and Neurological Disorders at the University of California, Irvine. "But I think there's an imperative for us to find ways to move forward."

Grill got a close-up view of the challenge in July when COVID-19 cases were spiking nationwide as he was trying to launch a study.

UC Irvine and dozens of other research centers had just begun enrolling participants in the AHEAD study, a global effort that will test whether an investigational drug can slow down the earliest brain changes associated with Alzheimer's disease.

Finding individuals willing and able to sign up for this sort of research is difficult even without a pandemic, says Grill, who also co-directs recruitment for the Alzheimer's Clinicals Trial Consortium, funded by the National Institute on Aging.

"We're asking people do a lot, including enroll in long studies that require numerous visits," he says, "and in the AHEAD study, taking an investigational drug or placebo that's injected into a vein."

Participants will receive either a placebo or a drug called BAN2401, made by Eisai, which is meant to reduce levels of amyloid, a toxic protein associated with Alzheimer's. People in the study will also have positron emission tomography, or PET, scans of their brains to measure changes in amyloid and another toxic protein called tau.

Researchers know that for participants, every visit represents a potential exposure to the coronavirus. That's a sobering thought, given that some of those participants are as old as 80, Grill says.

So, like most research centers, UC Irvine has implemented a long list of safety measures.

Medical staff get daily screenings, patient visits are spaced out to avoid overlaps, exam rooms get extra cleaning, and personal protective equipment is the norm.

"We think we can minimize that risk to an extent necessary to move these studies forward, and that it's urgent that we do that," Grill says.

So far, Grill says, the measures appear to be working. Participants aren't getting infected, and they are signing up.

"I've just been completely, totally inspired by the people enrolled in these studies, the majority of whom really want us to push ahead," he says.

Of course, some people have dropped out, saying the risk of infection is too great. Also, recruiting has become difficult in African American and Latino communities, which have been especially hard hit by COVID-19, Grill says.

The fear in these communities became obvious early in the pandemic, says Crystal Glover, a social psychologist who is in charge of community outreach at the Rush Alzheimer's Disease Center in Chicago.

"They had heard about COVID; they heard that we had patients there that were being treated for COVID," she says. "And they indicated that they did not want to come to our institution."

So Glover has been focusing on solutions and advising recruitment efforts at other centers, including those involved in the AHEAD study.

Her message is straightforward: "If we are looking to enroll folks now, we need to reach back out to the communities in which we already have relationships," she says.

For Rush, that has meant offering support and services to minority communities before asking for participation in research.

"We've had town halls, we've had [personal protective equipment] drives, we've had webinars on the proper use of PPE, food delivery, food drives," Glover says.

When fears are high, she says, researchers also need to explain why a particular study matters to a specific community.

"We know that these chronic diseases of aging are really impacting Blacks and Latinos at higher rates than non-Latino whites," Glover says. "I lead in with that."

Then she goes on to explain "why this is relevant, it's not only relevant to you but also to your family and future generations."

Rush is also trying some new tactics to reach minority communities during the pandemic. One involves staging health and wellness events at laundromats that are owned by women and people of color and that serve essential workers.

Glover says people who show up can wash their clothes for free in a place where social distancing is strictly maintained. And they may also learn a bit about research on Alzheimer's disease.

"We have that information for them at the laundromat," She says. "But they get to wash their clothes and stay safe during COVID-19."

Such efforts are crucial right now, Grill says.

"The hope is that a year from now COVID is a thing of the past," he says. "We know that Alzheimer's disease is going to continue to get worse."

Copyright 2020 NPR. To see more, visit https://www.npr.org.

ARI SHAPIRO, HOST:

When COVID-19 arrived, medical centers put a lot of research studies on hold. Now scientists are finding ways to safely continue clinical trials despite the pandemic. NPR's Jon Hamilton has more.

JON HAMILTON, BYLINE: Getting people to sign up for research studies was really hard back in July, when COVID-19 seemed to be everywhere. And that's when Josh Grill, a researcher at the University of California Irvine, began recruiting people for a nationwide study of a potential Alzheimer's drug.

JOSH GRILL: It's been a struggle, of course.

HAMILTON: Grill is part of the AHEAD Study, which will show whether a drug called BAN2401 can prevent or delay Alzheimer's. He says participants in this sort of research make a big commitment even without a pandemic going on.

GRILL: We're asking people to do a lot, including enroll in long studies that require numerous visits and, in the AHEAD Study, taking an investigational drug or placebo that's injected into a vein.

HAMILTON: Every visit represents a potential exposure to the coronavirus, and Grill says that's a sobering thought when you're recruiting people as old as 80.

GRILL: We do study the population that is at greatest risk for negative health outcomes when it comes to COVID.

HAMILTON: So like other research centers, UC Irvine has implemented a long list of safety measures. Grill says medical staff get daily screenings, patient visits are spaced out, exam rooms get extra cleaning, and personal protective equipment is the norm.

GRILL: We think we can minimize that risk to an extent necessary to be able to move these studies forward and that it's urgent that we do that.

HAMILTON: Grill says the measures appear to be working, and participants are showing up.

GRILL: I've just been completely, totally inspired by the people enrolled in these studies, the majority of whom really want us to push ahead.

HAMILTON: One ongoing challenge, though, is recruiting African Americans and Latinos. Crystal Glover is in charge of outreach at the Rush Alzheimer's Disease Center in Chicago.

CRYSTAL GLOVER: They had heard about COVID. They heard we had patients there that were being treated for COVID. And they indicated that they did not want to come to our institution.

HAMILTON: So Glover, a social psychologist, has been offering some advice to research centers.

GLOVER: If we are looking to enroll folks now, we need to reach back out to the communities in which we already have relationships.

HAMILTON: Glover says for Rush, that has meant offering support and services before asking for participation.

GLOVER: We've had town halls. We've had PPE drives. We've had webinars on the proper use of PPE, food delivery, food drives.

HAMILTON: Glover says researchers also need to explain why a particular study matters to a specific community.

GLOVER: We know that these chronic diseases of aging are really impacting Blacks and Latinos at higher rates than non-Latino whites. I lead in with that. That's why this is relevant. It's not only relevant to you but also to your family and future generations.

HAMILTON: Glover says she's also trying some new tactics. One involves staging health and wellness events at laundromats that are owned by women and people of color and that serve essential workers. Glover says people who show up can wash their clothes for free in a place where social distancing is strictly maintained, and they may even learn a bit about research on Alzheimer's disease.

GLOVER: We have that information for them at the laundromat, but they get to wash their clothes and stay safe during COVID-19.

HAMILTON: Josh Grill of UC Irvine says efforts like that are crucial because when the pandemic is over, Alzheimer's will still be a huge problem. Jon Hamilton, NPR News. Transcript provided by NPR, Copyright NPR.